Research starter report
Deep Learning Approaches for Protein Structure Prediction from Sequence
- Field
- Biology / Life Sciences
- Papers
- 15, every DOI checked against Crossref
- Sources
- Semantic Scholar, OpenAlex, Crossref
Field overview
Determining the three-dimensional structure of a protein from its one-dimensional amino acid sequence, known as the protein folding problem, has been one of the central challenges in molecular biology for over half a century.
Reading order
Before and after AlphaFold2: An overview of protein structure prediction
Letícia Machado Favery Bertoline et al., 2023. Frontiers in Bioinformatics. doi:10.3389/fbinf.2023.1120370 312 citations
Start here: this historical overview of protein structure prediction before and after AlphaFold2 gives essential context for understanding where the field came from and why the deep learning revolution mattered.
Protein structure prediction via deep learning: an in-depth review
Yajie Meng et al., 2025. Frontiers in Pharmacology. doi:10.3389/fphar.2025.1498662 39 citations
Read after the historical overview, as this in-depth review of deep learning methods for protein structure prediction consolidates the broader technical landscape and prepares you for diving into specific architectures.